torsdag 11 augusti 2011

Cannabis dödar hjärnceller?

I Sverige dödar cannabis hjärnceller. Det vet vi. Det är sant. Staten & myndigheterna säger det, alltså måste det vara sant. Här är en av de studier som "bevisar" att cannabis dödar hjärnceller. Läs sammanfattningen, det är nämligen intressant att se svart på vitt vad svenska staten & myndigheter baserar sin narkotikapolitik på...Studien är gjord 1980. Inget fel i detta, studien behöver inte vara oriktig och sakna vetenskaplig förankring för att den är gammal. MEN, för att en studie SKA vara vetenskapligt förankrad, alltså ha hög evidensstyrka MÅSTE den uppfylla de internationellt fastställda vetenskapliga kriterierna. Se tidigare inlägg för utförligare förklaring av vetenskaplig förankring och evidensstyrka.

Tillbaka till studien som svenska staten & myndigheterna använder för att "bevisa" att cannabis är både farligt och skadligt. För det första, på samma sida finns länkat till 2 studier som motsäger att cannabis dödar hjärnceller. Här finns en studie från 2011 där man funnit att cannabis skyddar hjärnceller, till och med reparerar skadade hjärnceller. Dessutom, tidigare i bloggen refererar jag till ett antal stora rapporter som jag gav namnet *Science*. Ingen av dessa rapporter tar upp att cannabis skadar eller dödar hjärnceller. Här är en annan omfattande studie (Cannabis and the brain) som också motsäger att cannabis skadar eller dödar hjärnceller. Istället tar den upp att studien som "bevisar" att cannabis dödar hjärnceller har väldigt låg evidensstyrka. Varför? Väldigt få studier har kunnat reproducera resultatet, alltså att cannabis dödar hjärnceller! Cannabis and the brain nämner också ett antal studier där resultatet visar att cannabis har neuroskyddande egenskaper, alltså skyddar hjärnceller från skador.   


Några referenser till på att cannabis har neuroskyddande egenskaper:

The Journal of Neuroscience

PubMed

Hampson AJ, Grimaldi M, Axelrod J, Wink D. Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proc Natl Acad Sci USA 1998 Jul 7;95(14):8268-73

Van der Stelt M, Veldhuis WB, Bar PR, Veldink GA, Vliegentharet JF, Nicolay K. Neuroprotection by Delta9-tetrahydrocannabinol, the main active compound in marijuana, against ouabain-induced in vivo excitotoxicity. J Neurosci 2001 Sep 1;21(17): 6475-

Mechoulam R, Hanu L. The cannabinoids: an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection. Pain Res Manag 2001 Summer;6(2): 67-73. 

Mechoulam R, Spatz M, Shohami E. Endocannabinoids and neuroprotection. Sci STKE Apr 23;2002(129):RE5

Ritch R. Neuroprotection: is it already applicable to glaucoma therapy? Curr Opin Opthalmol 2000 Apr;11(2): 78-


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pdficonKim, SH, Won, SJ, Mao, XO, Ledent, C, Jin, K & Greenberg, DA. (2006). Role for neuronal nitric-oxide synthesis in cannabinoid-induced neurogenesis.  The Journal of Pharmacology and Experimental Therapeutics.  319(1): 150-154.

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pdficonMechoulam R, & Hanu L. (2001).  The cannabinoids: an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection.  Pain Res Manag., 6(2), 67-73.

pdficonSagredo, O., Garcia-Arencibia, M., de Lago, E., Finette, S., Decio, A. & Fernandez-Ruiz, J. (2007). Cannabinoids and neuroprotection in basal ganglia disorders.  Molecular Neurobiology, 36(1): 82-91.

pdficonShouman B, Fontaine RH, Baud O, Schwendimann L, Keller M, Spedding, M, Lelièvre, V & Gressens,P. (2006).  Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor-mediated excitotoxic damage.  Brtish Journal of Pharmacology., 148(4), 442-51.

pdficonSun, Y., Alexander, S.P.H., Garle, M.J., Gibson, C.L., Hewitt, K., Murphy, S.P., Kendall, D.A. & Bennett, A.J. (2007). Cannabinoid activation of PPAR alpha, a novel neuroprotective mechanism.  British Journal of Pharmacology.  152: 734-743.

pdficonvan der Stelt M, Veldhuis WB, Bär PR, Veldink GA, Vliegenthart JF, & Nicolay,K. (2001).  Neuroprotection by Delta9-tetrahydrocannabinol, the main active compound in marijuana, against ouabain-induced in vivo excitotoxicity.  Journal of Neuroscience. 21(17), 6475-9.

pdficonWitting A, Chen L, Cudaback E, Straiker A, Walter L, Rickman, B, Möller, T, Brosnan, C & Stella, N. (2006).  Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection.  Proc Natl Acad Sci U S A., 103(16), 6362-7.

pdficonZani, A., Braida, D., Capurro, V. & Sala, M. ( 2007).  ?9-tetrahydrocannabinol (THC) and AM 404 protect against cerebral ischaemia in gerbils through a mechanism involving cannabinoid and opioid receptors.  British Journal of Pharmacology. 152: 1301-1311.

pdficonZhang M, Martin BR, Adler MW, Razdan RK, Ganea D, & Tuma, RF. (2008).  Modulation of the balance between cannabinoid CB(1) and CB(2) receptor activation during cerebral ischemic/reperfusion injury.  Neurosci.,152(3), 753-60.

Aguado T, Romero E, Monory K, Palazuelos J, Sendtner M, et.al. (2007).  The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis.  J Biol Chem., 282(33), 23892-8.

Alger BE. (2004).  Endocannabinoids and their implications for epilepsy.  Epilepsy Curr., 4(5), 169-73.
Amtmann et al (2004).  Survey of cannabis use in patients with amyotrophic lateral sclerosis.  The American Journal of Hospice and Palliative Care21: 95-104

Carter, G. T., & Rosen, B. S. (2001). Marijuana in the management of amyotrophic lateral sclerosis. Am J Hosp Palliat Care, 18(4), 264-270.

Carter GT & Rosen BS (2003). Drug therapy for amyotrophic lateral sclerosis: Where are we now?  The Investigational Drugs Journal, 6: 147-153.

Chen J, Lee CT, Errico SL, Becker KG, & Freed WJ. (2007).  Increases in expression of 14-3-3 eta and 14-3-3 zeta transcripts during neuroprotection induced by delta9-tetrahydrocannabinol in AF5 cells. J Neurosci Res., 85(8), 1724-33.

Croxford & Yamamura (2005). Cannabinoids and the immune system: Potential for the treatment of inflammatory diseases.  Journal of Neuroimmunology. 166: 3-18.

Curtis A & Rickards H. (2006). Nabilone could treat chorea and irritability in Huntington’s disease.  Journal Neuropsychiatry Clin Neurosci. 18(4):553-4.

Ehrhart, J, Obregon, D, Mori, T, Hou, H, Sun, N, Bai, Y, Klein, T, Fernandez, F, Tan, J & Shytle, RD. (2005).  Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation.  J. Neuroinflam., 2(29),  doi:10.1186/1742-2094-2-29.

El-Remessy AB, Khalil IE, Matragoon S, Abou-Mohamed G, Tsai NJ, Roon P, Caldwell RB. Caldwell RW, Green K & Liou GI. (2003).  Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite.  American Journal of Pathology. 163(5), 1997-2008.

Guzman, M., Duarte, M. J., Blazquez, C., Ravina, J., Rosa, M. C., Galve-Roperh, I., et al. (2006). A pilot clinical study of Delta(9)-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme. Br J Cancer, 95(2), 197-203.

Hampson, A. J., Grimaldi, M., Axelrod, J., & Wink, D. (1998). Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proc Natl Acad Sci U S A, 95(14), 8268-8273.
Lu et al. (2006).  The cannabinergic system as a target for anti-inflammatory therapies.  Current Topics in Medicinal Chemistry 13: 1401-1426. 
 
Palazuelos, J., Davoust, N., Julien, B., Hatterer, E., Aguado, T., Mechoulam, R., Benito, C., Romero, J., Silva, A., Guzmán, M., Nataf, S. & Galve-Roperh, I. (2008). The CB2 cannabinoid receptor controls myeloid progenitor trafficking.  The Journal of Biological Chemistry.  283(19): 13320-13329.

Panikashvile D, Mechoulam R, Beni SM, Alexandrovich A & Shohami E. (2005). CB1 cannabinoid receptors are involved in neuroprotection via NF-?B inhibition. Journal of Cerebral Blood Flow & Metabolism. 25: 477-84.

Pryce G, Ahmed Z, Hankey DJ, Jackson SJ, Croxford JL, Pocock, JM, Ledent, C, Petzold, A, Thompson, AJ, Giovannoni, G, Cusner, ML & Baker, D. (2003).  Cannabinoids inhibit neurodegeneration in models of multiple sclerosis.  Brain, 126(10), 2191-202.

Raman C, McAllister SD, Rizvi G, Patel SG, Moore DH & Abood ME (2004). Amyotrophic lateral sclerosis: delayed disease progression in mice by treatment with a cannabinoid.  Amyotrophic Lateral Sclerosis & Other Motor Neuron Disorders, 5: 33-39.

Ramírez, B.G., Blázquez, C., del Pulgar, T.G., Guzmán, M. & de Ceballos, M.L. (2005). Prevention of Alzheimer’s disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation.  The Journal of Neuroscience, 25(8): 1904-1913.

Venderova, K., Ruzicka, E., Vorisek, V., & Visnovsky, P. (2004). Survey on cannabis use in Parkinson's disease: Subjective improvement of motor symptoms. Mov Disord, 19(9), 1102. 
 
Volicer, L., Stelly, M., Morris, J., McLaughlin, J., & Volicer, B. J. (1997). Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease. Int J Geriatr Psychiatry, 12(9), 913-919.

Walther, S., Mahlberg, R., Eichmann, U., & Kunz, D. (2006). Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia. Psychopharmacology (Berl), 185(4), 524-528.
 

 

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